Tuesday, August 26, 2008

Nano-particles to ensure better absorption of antioxidants

August 26th, 2008 - 3:53 pmWashington, Aug 26 (IANS)

Researchers have designed a nano-sized “trojan horse” particle to ensure better absorption of healing antioxidants by the body. Antioxidants are known to neutralise the harmful effect of free radicals and other reactive chemical species that are constantly generated by our body and are thought to promote better health.

Fruits like papaya, guava and vegetables like tomatoes (lycopene) are natural sources of antioxidants.

Ken Ng and Ian Larson of Monash University’s have designed a nanoparticle, one thousandth the thickness of a hair, that protects antioxidants from being destroyed in the gut and ensures a better chance of them being absorbed in the digestive tract.

Normally the body’s own antioxidant defence is sufficient, but in high-risk individuals, such as those with a poor diet or those at risk of developing atherosclerosis, diabetes or Alzheimer’s disease, a nutritional source of antioxidants is required.

Larson said orally delivered antioxidants were easily destroyed by acids and enzymes in the human body, with only a small percentage of what is consumed actually being absorbed.

The solution is to design a tiny sponge-like chitosan biopolymeric nanoparticle as a protective vehicle for antioxidants. Chitosan is a natural substance found in crab shells.

“Antioxidants sit within this tiny trojan horse, protecting it from attack from digestive juices in the stomach,” Larson said.

“Once in the small intestine the nanoparticle gets sticky and bonds to the intestinal wall. It then leaks its contents directly into the intestinal cells, which allows them to be absorbed directly into the blood stream.

“We hope that by mastering this technique, drugs and supplements also vulnerable to the digestive process can be better absorbed by the human body,” said Larson.

The research project will proceed to trials early in 2009.