International Application No.: PCT/US2009/040688
International Filing Date: 15.04.2009
SONNEMED LLC [US/US]; 10 Mt. Vernon Street, #208 Winchester, MA 01890 (US) (All Except US).
LEWIS, Thomas [US/US]; (US) (US Only).
SZULWACH, Ann, M. [US/US]; (US) (US Only).
BURKE, Donald; .
LEWIS, Thomas; (US).
COMPOUNDS AND METHODS FOR ACTIVATED THERAPY
Provided herein are compounds for detection, diagnosis and treatment of target tissues or target compositions, including hyperproliferative tissues such as tumors, using sonodynamic and/or photodynamic methods. In particular, photosensitizer and/or sonosensitizer compounds that collect in hyperproliferative tissue are provided.
The compounds of the invention are useful as sonosensitizers, photosensitizers and/or as dual acting sensitizers as therapeutic and diagnostic agents, for example for treatment of several cancer types such as, but not limited to, melanoma, prostate, brain, colon, ovarian, breast, skin, lung, esophagus and bladder cancers and other hormone-sensitive tumors, as well as for treatment of age-related macular degeneration, and for killing cells, viruses, fungi and bacteria in samples and living tissues as well known in the art of PDT and other sonosensitizer applications.
The invention further relates to a method of sonodynamic therapy, which comprises administering to an individual in need an effective amount of a compound of the invention, followed by local ultrasound. The compounds of the invention are also useful for photo- and sonodestruction of normal or malignant animal cells, as desired, as well as of microorganisms in culture, enabling selective photo- and sonodestruction of certain types of cells in culture or infective agents. Thus, the invention further provides the use of the compounds of the invention for in vivo, ex-vivo or in vitro killing of cells or infectious agents such as bacteria, viruses, parasites and fungi in a biological product, e.g. blood, which comprises treating the infected sample with the compound of the invention followed by ultrasound of the sample. Examples of such diseases or conditions include acne, Aids, viral hepatitis, diabetic retinopathy, infection with sars virus, coronary artery stenosis, carotid artery stenosis, intermittent claudication, or Asian (chicken) flu virus, or infections caused by intracellular infectious agents such as Clamidia, tox, ricetzia, rocky mountain spotted fever, q-fever, and others.
Posted by donpatent at 2:24 PM
See also United States Patent Application 20090275548