EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent

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Authors Li X, Ye X, Qi J, Fan R, Gao X, Wu Y, Zhou L, Tong A, Guo G
Received 15 January 2016
Accepted for publication 10 May 2016
Published 17 August 2016 Volume 2016:11 Pages 3993—4009
DOI https://dx.doi.org/10.2147/IJN.S104350
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Yu Mi
Peer reviewer comments 3
Editor who approved publication: Dr Lei Yang

Xiaoling Li,1 Xianlong Ye,2 Jianying Qi, 2 Rangrang Fan,1 Xiang Gao,1 Yunzhou Wu,2 Liangxue Zhou,1Aiping Tong,1 Gang Guo1

1State Key Laboratory of Biotherapy and Cancer Center, Department of Neurosurgery, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, People’s Republic of China;
2College of Life Science, Northeast Agriculture University, Harbin, People’s Republic of China

Abstract: 
Wound healing is a complex multifactorial process that relies on coordinated signaling molecules to succeed. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair; however, precise control over its application is necessary to reduce the side effects and achieve desired therapeutic benefits. Moreover, the extensive oxidative stress during the wound healing process generally inhibits repair of the injured tissues. Topical applications of antioxidants like curcumin (Cur) could protect tissues from oxidative damage and significantly improve tissue remodeling. To achieve much accelerated wound healing effects, we designed a novel dual drug co-loaded in situ gel-forming nanoparticle/hydrogel system (EGF-Cur-NP/H) which acted not only as a supportive matrix for the regenerative tissue, but also as a sustained drug depot for EGF and Cur. In the established excisional full-thickness wound model, EGF-Cur-NP/H treatment significantly enhanced wound closure through increasing granulation tissue formation, collagen deposition, and angiogenesis, relative to normal saline, nanoparticle/hydrogel (NP/H), Cur-NP/H, and EGF-NP/H treated groups. In conclusion, this study provides a biocompatible in situ gel-forming system for efficient topical application of EGF and Cur in the landscape of tissue repair.

Keywords:
epidermal growth factor, EGF, curcumin, wound healing, thermosensitive hydrogel, nanoparticles

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