CANCER CELL TARGETING USING NANOPARTICLES

(WO/2008/121949)

Pub. No.: WO/2008/121949 International Application No.: PCT/US2008/058873 Publication Date: 09.10.2008 International Filing Date: 31.03.2008
IPC:	A61K 9/14 (2006.01), B82B 1/00 (2006.01)
Applicants:	MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; Room NE25-230, 5 Cambridge Center, Kendall Square, Cambridge, MA 02142 (US) (All Except US). ZALE, Stephen, E. [US/US]; 101 Binney Street, Cambridge, MA 02142 (US) (US Only).
Inventor:	ZALE, Stephen, E.; 101 Binney Street, Cambridge, MA 02142 (US).
Agent:	HANLEY, Elizabeth, A.; Lahive & Cockfield, LLP, One Post Office Square, Boston, MA 02109-2127 (US).
Priority Data:	PCT/US2007/007927 30.03.2007 US 60/976,197 28.09.2007 US

Title:

CANCER CELL TARGETING USING NANOPARTICLES

Abstract:

The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries. Source