|Latest bibliographic data on file with the International Bureau |
|IPC:||B81B 3/00 (2006.01)|
|Applicants:||WILLIAM MARSH RICE UNIVERSITY [US/US]; 6100 Main Street, Houston, TX 77005 (US) (All Except US).|
SCHMIDT, Howard, K. [US/US]; (US) (US Only).
DUQUE, Juan, G. [US/US]; (US) (US Only).
PASQUALI, Matteo [IT/US]; (US) (US Only).
|Inventors:||SCHMIDT, Howard, K.; (US).|
DUQUE, Juan, G.; (US).
PASQUALI, Matteo; (US).
|Agent:||SHADDOX, Robert, C.; Winstead PC, P.O. Box 50784, Dallas, TX 75201 (US).|
 The present inventors observed clear evidence that SWNT behave as antennas in the presence of light, microwaves and radio frequency fields. The present inventors also found a mechanism to produce high yields of SWNT rings and novel split-ring structures. The present inventors contemplate that these results support the idea that EM-stimulated therapies based on SWNT antennas are possible, and that tunable structures may be developed to optimize RF thermoablation therapies.
 The present inventors anticipate that using SWNT, or similar elongated conductive particles, to generate free radicals in solution may be useful for a variety of applications. By way of example and not limitation, one application may be as a cytotoxic agent in healthcare. In conjunction with a targeting, or localization process, the present process may include stimulating the SWNT with body-penetratine electric fields to generate high concentrations of ROS (Reactive Oxygen Species). These may then have a toxic effect on local tissues. The fields may be localized further by using phased array electro-magnetic sources. This field emission mediated process may be non-linearly dependent (as all field emission processes, described by Fowler-Nordheim i-v curves are) on the applied field and the length of the antennas (length of SWNT). Further the present inventors expect that controlled precipitation/bundling of SWNT (by targeting multiple SWNT to a given target cell) may 'construct' antennae long enough to produce ROS, while individual SWNT may remain essentially inert under electric stimulation. By one or a combination of these means, the present process and nanostructured materials may readily achieve a very selective agent for destroying undesirable tissues, e.g. cancer, perhaps even at the level of individual cells. This may tend to be more desirable than the generalized cytotoxins or radiation-based treatments commonly used today.